CDC37 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• In S
• cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK′s)
• Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase
• Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37
• It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90
• Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src
• More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90
• In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.