FOXP1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predict Transcriptional repressor (PubMed:18347093, PubMed:26647308)
• Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential
• Plays an important role in the specification and differentiation of lung epithelium
• Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2
• Essential transcriptional regulator of B-cell development
• Involved in regulation of cardiac muscle cell proliferation
• Involved in the columnar organization of spinal motor neurons
• Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections
• The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins
• Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3
• Negatively regulates the differentiation of T follicular helper cells T(FH)s
• Involved in maintaice of hair follicle stem cell quiescence; the function probably involves regulation of FGF18
• Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198)
• Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093)
• Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716)
• Can negatively regulate androgen receptor signaling (PubMed:18640093)
• {ECO:0000250; UniProtKB:P58462, ECO:0000269; PubMed:15286807, ECO:0000269; PubMed:18640093, ECO:0000269; PubMed:18799727, ECO:0000269; PubMed:24023716, ECO:0000269; PubMed:25267198, ECO:0000269; PubMed:26647308, ECO:0000305; PubMed:18347093, ECO:0000305; PubMed:24023716}.; Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs)
• Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes
• Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5′-CGATACAA-3′ (or closely related sequences) (PubMed:21924763)
• Promotes ESC self-renewal and pluripotency
• {ECO:0000250; UniProtKB:P58462, ECO:0000269; PubMed:21924763}.