Ku70 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Single-stranded DNA-dependent ATP-dependent helicase
• Has a role in chromosome translocation
• The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner
• It works in the 3′-5′ direction
• Binding to DNA may be mediated by XRCC6
• Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination
• The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold
• The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together
• The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step
• Required for osteocalcin gene expression
• Probably also acts as a 5′-deoxyribose-5-phosphate lyase (5′-dRP lyase), by catalyzing the beta-elimination of the 5′ deoxyribose-5-phosphate at an abasic site near double-strand breaks
• 5′-dRP lyase activity allows to ′clean′ the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined
• The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.