TBX3 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box
• T-box genes encode transcription factors involved in the regulation of developmental processes
• The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb
• Tbx3 is required for normal mammary development and is also implicated in tumor development
• Tbx3 expression also increases during osteoblast differentiation, and may function as a determit of osteoblast cell numbers
• Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development
• Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined
• Subsets of human breast cancer cell lines overexpress TBX36
• in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells
• Truncated forms of Tbx3 are increased in plasma samples.