ELK1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors
• ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus
• Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1
• ELK1 appears to be a direct target of activated MAP kinase
• Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo
• ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade
• Alternatively spliced transcript variants encoding the same protein have been found for ELK1.