PRKAR1A Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan cAMP is a signaling molecule important for a variety of cellular functions
• cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins
• The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits
• cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
• Four different regulatory subunits and three catalytic subunits have been identified in humans
• This gene encodes one of the regulatory subunits
• This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids
• Mutations in this gene cause Carney complex (CNC)
• This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2
• A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40)
• Three alternatively spliced transcript variants encoding the same protein have been observed.