Integrin Beta 1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits
• More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals
• In general, integrins function as receptors for extracellular matrix proteins
• Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells
• Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis
• There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids
• Their distribution pattern in adult tissues is mutually exclusive
• beta1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant.