WWOX Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing
• This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD)
• The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate
• This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism
• The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein
• In addition, there is evidence that this gene behaves as a suppressor of tumor growth
• Alternative splicing of this gene generates transcript variants that encode different isoforms.