ROR2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes
• It seems to be required for cartilage and growth plate development
• This Type I membrane protein is expressed at high levels during early embryonic development
• The expression levels drop strongly around day 16 and there are only very low levels in adult tissues
• Defects in ROR2 are a cause of brachydactyly type B1 (BDB1)
• BDB1 is an autosomal domit skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails
• In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent
• Both fingers and toes are affected
• The thumbs and big toes are usually deformed
• Defects in ROR2 are a cause of recessive Robinow syndrome (RRS)
• RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance
• The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.