FNTA Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Principal Names: Farnesyltransferase, CAAX box (FNTA); alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit; Official Gene Symbol: FNTA Gen Bank Accession Number: NP_002018, Gene ID: 2339 (human) Gene Map Locus: 8p11 (human) Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases
• The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2.5.1.21), which is alpha-beta heterodimeric enzyme
• It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box
• FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases
• Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras
• Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.