AC9 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules
• Cyclic AMP, in turn, activates several other target molecules (primarily cyclic AMP-dependent protein kinases) to control a broad range of diverse phenomena such as metabolism, gene transcription and memory
• Classically, adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins
• The binding of an agonist to a Gs-coupled receptor (i.e., alpha beta-adrenergic receptor) catalyzes the exchange of GDP (bound to G alpha s) for GTP, dissociation of GTP-G alpha sfrom G beta gamma and G alpha s-mediated activation of adenylyl cyclase
• The most abundant cerebral adenylyl cyclases appears to be adenylyl cyclase IX
• AC IX is confined to the gray matter and its expression is mainly neuronal, with its highest expression located at the hippocampus
• ACIX is also expressed in heart, pancreas and thyrocytes
• AC I and AC IX are regulated reciprocally by intracellular free Ca2+
• The inhibition of AC IX by Ca2+ is blocked by the calcineurin inhibitors FK506 and cyclosporin A.