Thioredoxin Reductase 1/TXNRD1/TRXR1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• This gene encodes a member of the family of pyridine nucleotide oxidoreductases
• This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress
• The functional enzyme is thought to be a homodimer which uses FAD as a cofactor
• Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity
• The selenocysteine is encoded by the UGA codon that normally signals translation termination
• The 3′ UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal
• Alternative splicing results in several transcript variants encoding the same or different isoforms.