ZCCHC6 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay
• Essential for both oocyte maturation and fertility
• Through 3′ terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth
• Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets
• Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms
• Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7)
• Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation
• Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A
• In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3′ end overhang for efficient processing
• Add oligo-U tails to truncated pre-miRNAS with a 5′ overhang which may promote rapid degradation of non-functional pre-miRNA species
• Does not play a role in replication-dependent histone mRNA degradation
• Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.