50-157-02
TNF alpha Monoclonal Antibody (TN3-19.12), Biotin, Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-02-Each-of-1 | In Stock | ₹ 34,737.36 |
50-157-02 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,737.36
GST (18%): ₹ 6,252.725
Total Price: ₹ 40,990.085
Antigen
TNF alpha
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P06804, P16599
Gene Symbols
Tnf
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
21926, 24835
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay
Clone
TN3-19.12
Conjugate
Functional Grade
Gene
Tnf
Gene Alias
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species
Armenian Hamster
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Description
- Description: The TN3-19.12 monoclonal antibody reacts with mouse, rat, and rabbit tumor necrosis factor-alpha (TNF-alpha), but not with human TNF-alpha
- The TN3-19.12 antibody is a neutralizing antibody
- Mouse TNF-alpha is a 17 kDa factor produced by macrophages, monocytes, neutrophils, CD4+ T cells and NK cells
- A 26 kDa form of TNF-alpha is expressed as a membrane-bound molecule
- TNF-alpha is cytolytic and plays an important role in immune regulation
- Dimers and trimers of TNF-alpha have been observed
- Applications Reported: The Functional Grade Biotin anti-mouse TNF alpha antibody (clone TN3-19) has been reported for use as the in vivo capture antibody for the In Vivo Cytokine Capture Assay (IVCCA)
- The IVCCA facilitates measurement of cytokines in serum by increasing their in vivo half lives dramatically
- This increases the sensitivity of measurement of in vivo cytokine production 30- to 1000- fold
- For detailed methodology in this application, please refer to Finkelman, F., S
- Morris, T
- Orekhova, and D
- Sehy
- 2003
- The In Vivo Cytokine Capture Assay for measurement of cytokine production in the mouse
- In Current Protocols in Immunology
- Unit 6.28
- J
- Coligan, A
- Kruisbeek, D
- Margulies, E
- Shevach, and W
- Strober, eds
- John Wiley and Sons, New York The TN3-19.12 antibody has been reported for use in intracellular staining for flow cytometric analysis, cytokine neutralization, and ELISA
- Fluorochrome conjugated TN3-19
- TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily
- This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR
- TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation
- TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions
- Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice
- Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors
- TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity
- This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
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Show Difference
Antigen: TNF alpha
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with no preservative; pH 7.2
Gene Accession No.: P06804, P16599
Gene Symbols: Tnf
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 21926, 24835
Content And Storage: 4° C
Form: Liquid
Applications: Functional Assay
Clone: TN3-19.12
Conjugate: Functional Grade
Gene: Tnf
Gene Alias: APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species: Armenian Hamster
Quantity: 500 μg
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
TNF alpha
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with no preservative; pH 7.2
Gene Accession No.:
P06804, P16599
Gene Symbols:
Tnf
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
21926, 24835
Content And Storage:
4° C
Form:
Liquid
Applications:
Functional Assay
Clone:
TN3-19.12
Conjugate:
Functional Grade
Gene:
Tnf
Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species:
Armenian Hamster
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: SHMT2
Classification: Polyclonal
Concentration: __
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: P34897, Q9CZN7
Gene Symbols: SHMT2
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 108037, 6472
Content And Storage: 4° C
Form: Liquid
Applications: Western Blot
Clone: __
Conjugate: Unconjugated
Gene: SHMT2
Gene Alias: GLYA, SHMT, GLY A+, glycine auxotroph A, human complement for hamster, glycine hydroxymethyltransferase, serine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase, mitochondrial, serine methylase, threonine aldolase
Host Species: Rabbit
Quantity: 20 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
SHMT2
Classification:
Polyclonal
Concentration:
__
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
P34897, Q9CZN7
Gene Symbols:
SHMT2
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
108037, 6472
Content And Storage:
4° C
Form:
Liquid
Applications:
Western Blot
Clone:
__
Conjugate:
Unconjugated
Gene:
SHMT2
Gene Alias:
GLYA, SHMT, GLY A+, glycine auxotroph A, human complement for hamster, glycine hydroxymethyltransferase, serine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase, mitochondrial, serine methylase, threonine aldolase
Host Species:
Rabbit
Quantity:
20 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: SNTA1
Classification: Polyclonal
Concentration: 1 mg/ml
Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.: Q13424
Gene Symbols: SNTA1
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6640
Content And Storage: 4° C
Form: Liquid
Applications: Western Blot
Clone: __
Conjugate: Unconjugated
Gene: SNTA1
Gene Alias: RP23-192L3.1, AW228934, Snt1
Host Species: Rabbit
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SNTA1
Classification:
Polyclonal
Concentration:
1 mg/ml
Formulation:
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Accession No.:
Q13424
Gene Symbols:
SNTA1
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6640
Content And Storage:
4° C
Form:
Liquid
Applications:
Western Blot
Clone:
__
Conjugate:
Unconjugated
Gene:
SNTA1
Gene Alias:
RP23-192L3.1, AW228934, Snt1
Host Species:
Rabbit
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: SNTA1
Classification: Polyclonal
Concentration: __
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.: Q13424
Gene Symbols: SNTA1
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6640
Content And Storage: 4° C
Form: Liquid
Applications: Western Blot
Clone: __
Conjugate: Unconjugated
Gene: SNTA1
Gene Alias: RP23-192L3.1, AW228934, Snt1
Host Species: Rabbit
Quantity: 20 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
SNTA1
Classification:
Polyclonal
Concentration:
__
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.:
Q13424
Gene Symbols:
SNTA1
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6640
Content And Storage:
4° C
Form:
Liquid
Applications:
Western Blot
Clone:
__
Conjugate:
Unconjugated
Gene:
SNTA1
Gene Alias:
RP23-192L3.1, AW228934, Snt1
Host Species:
Rabbit
Quantity:
20 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG