PELP1/MNAR Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors
• Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner
• Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol
• Plays a role in E2-mediated cell cycle progression by interacting with RB1
• May have important functional implications in ER/growth factor cross-talk
• Interacts with several growth factor signaling components including EGFR and HRS
• Involved in nuclear receptor signaling via its interaction with AR and NR3C1
• May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR
• Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K
• Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.