CENP-B Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• CENPB is a highly conserved protein that facilitates centromere formation
• It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family
• It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus
• It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation
• It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family
• It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus
• The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA
• This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.