SAFB1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rabbit, Orangutan, Monkey, Gorilla, Chimpanzee, hirteen-lined ground squirrel, Chinese hamster an This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA)
• This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein
• Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR
• This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes
• It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor
• This gene is a candidate gene for breast tumorigenesis.