KPNA4 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Panda, Orangutan, Monkey, Gorilla, Chimpanze Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism
• The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC
• Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers
• KPNA3 has been shown to be important in the TNF-a-induced nuclear import of NF-kappa-B
• It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells.