RPL7 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat, X
• tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Pa Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit
• Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins
• This gene encodes a ribosomal protein that is a component of the 60S subunit
• The protein belongs to the L30P family of ribosomal proteins
• It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2
• In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA
• The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus
• It is located in the cytoplasm
• The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus
• As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.