E2F1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• E2F1 is a member of the E2F family of transcription factors
• The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses
• The E2F proteins contain several evolutionally conserved domains found in most members of the family
• These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain
• This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain
• This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner
• It can mediate both cell proliferation and p53-dependent/independent apoptosis.