ERCC5/XPG Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Gorilla and Chimpanzee Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight
• The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages
• Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA
• The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region
• A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity
• A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity
• Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.