SRcyp Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan and Chimpanzee PPIG belongs to a highly conserved class of cyclophilins that function as peptidyl-prolyl-isomerases (PPIases) to catalyze the conversion of cis-proline to trans-proline in a polypeptide chain
• PPIG contains an amino-terminal cyclophilin domain followed by Nopp140 repeats that are involved in its function as a nuclear chaperone
• The carboxy-terminal of PPIG contains a SR (arginine-serine dipeptide repeat) domain that is involved in pre-mRNA splicing and processing
• PPIG interacts with the carboxy-terminal domain of RNA polymerase II as well as several other SR family splicing factors
• These interactions lead to changes in localization and conformation and suggest a regulatory role in transcription and pre-mRNA splicing in the elongating RNA polymerase complex
• PPIG is found in the nuclear matrix and nuclear speckles and is involved in the regulation of gene expression
• PPIG shows a predomitly diffuse cytoplasmic distribution at the onset of mitosis, and in late telophase the isomerase is recruited to the newly formed nuclei.