IDO1 Recombinant Rabbit Monoclonal Antibody (BLR031F), Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin
• By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines
• IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs)
• In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction
• The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms
• Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites
• Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregcy, autoimmunity, transplantation, and neoplasia.