CNOT1 Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this product is predicted to react with zebrafish, X
• tropicalis Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation
• Additional complex functions may be a consequence of its influence on mRNA expression
• Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3′UTRs
• Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36
• Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C
• Acts as a transcriptional repressor
• Represses the ligand-dependent transcriptional activation by nuclear receptors
• Involved in the maintece of emryonic stem (ES) cell identity.