CD160 Monoclonal Antibody (eBioCNX46-3 (CNX46-3)), eFluor™ 660, eBioscience™, Invitrogen™

Description

• CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the MAb BY55
• In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRgammadelta T cells, few NK cells and a minor subset of CD8+ T cells
• Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation
• In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160)
• In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells
• In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus
• CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules
• CD160 is expressed at the cell surface as a tightly disulfide-linked multimer
• It is involved in cell proliferation, cell surface receptor signaling pathways, cellular defense response, and regulation of immune response.