50-166-7018
MDM2 Mouse anti-Human, Clone: OTI17B3, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-7018-Each-of-1 | In Stock | ₹ 60,342.00 |
50-166-7018 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 60,342.00
GST (18%): ₹ 10,861.56
Total Price: ₹ 71,203.56
Antigen
MDM2
Classification
Monoclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
ACTFS, HDMX, hdm2
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI17B3
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human maligcies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Monoclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: ACTFS, HDMX, hdm2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI17B3
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
MDM2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
ACTFS, HDMX, hdm2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI17B3
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: DCC
Classification: Monoclonal
Conjugate: Unconjugated
Gene: DCC
Gene Alias: CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1630
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI5D10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P43146
Gene Symbols: DCC
Immunogen: Full length human recombit protein of human DCC produced in HEK293T cell.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
DCC
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
DCC
Gene Alias:
CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1630
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI5D10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P43146
Gene Symbols:
DCC
Immunogen:
Full length human recombit protein of human DCC produced in HEK293T cell.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: IKZF3
Classification: Monoclonal
Conjugate: Unconjugated
Gene: IKZF3
Gene Alias: AIO, AIOLOS, ZNFN1A3
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22806
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI4H7
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q9UKT9
Gene Symbols: IKZF3
Immunogen: Human recombit protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
IKZF3
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
IKZF3
Gene Alias:
AIO, AIOLOS, ZNFN1A3
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22806
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI4H7
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q9UKT9
Gene Symbols:
IKZF3
Immunogen:
Human recombit protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: RSPO1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: RSPO1
Gene Alias: CRISTIN3, RSPO
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 284654
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI2F10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q2MKA7
Gene Symbols: RSPO1
Immunogen: Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
RSPO1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
RSPO1
Gene Alias:
CRISTIN3, RSPO
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
284654
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI2F10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q2MKA7
Gene Symbols:
RSPO1
Immunogen:
Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1