50-166-7018
MDM2 Mouse anti-Human, Clone: OTI17B3, lyophilized, TrueMAB™
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-166-7018-Each-of-1 | In Stock | ₹ 58,009.68 |
50-166-7018 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 58,009.68
GST (18%): ₹ 10,441.742
Total Price: ₹ 68,451.422
Antigen
MDM2
Classification
Monoclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
ACTFS, HDMX, hdm2
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI17B3
Formulation
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
- 7KMWCO MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human maligcies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
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Antigen: MDM2
Classification: Monoclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: ACTFS, HDMX, hdm2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI17B3
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
MDM2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
ACTFS, HDMX, hdm2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI17B3
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
Human recombit protein fragment corresponding to amino acids 119-438 of human MDM2 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: DCC
Classification: Monoclonal
Conjugate: Unconjugated
Gene: DCC
Gene Alias: CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1630
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI5D10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: P43146
Gene Symbols: DCC
Immunogen: Full length human recombit protein of human DCC produced in HEK293T cell.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
DCC
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
DCC
Gene Alias:
CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1630
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI5D10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
P43146
Gene Symbols:
DCC
Immunogen:
Full length human recombit protein of human DCC produced in HEK293T cell.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: IKZF3
Classification: Monoclonal
Conjugate: Unconjugated
Gene: IKZF3
Gene Alias: AIO, AIOLOS, ZNFN1A3
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 22806
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI4H7
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q9UKT9
Gene Symbols: IKZF3
Immunogen: Human recombit protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
IKZF3
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
IKZF3
Gene Alias:
AIO, AIOLOS, ZNFN1A3
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
22806
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI4H7
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q9UKT9
Gene Symbols:
IKZF3
Immunogen:
Human recombit protein fragment corresponding to amino acids 1-301 of human IKZF3 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Antigen: RSPO1
Classification: Monoclonal
Conjugate: Unconjugated
Gene: RSPO1
Gene Alias: CRISTIN3, RSPO
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 284654
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Lyophilized
Applications: Western Blot
Clone: OTI2F10
Formulation: PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.: Q2MKA7
Gene Symbols: RSPO1
Immunogen: Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Antigen:
RSPO1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene:
RSPO1
Gene Alias:
CRISTIN3, RSPO
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
284654
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Lyophilized
Applications:
Western Blot
Clone:
OTI2F10
Formulation:
PBS with 8% trehalose and no preservative; pH 7.3
Gene Accession No.:
Q2MKA7
Gene Symbols:
RSPO1
Immunogen:
Human recombit protein fragment corresponding to amino acids 21-263 of human RSPO1 produced in E.coli.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1