TUBB2A Monoclonal Antibody (OTI3E6), TrueMAB™, OriGene

Description

• Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules
• Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintece
• Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3
• Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues
• Glutamate residues at the C-terminus of beta III tubulin can be glutamylated
• The precise function of such modifications is unclear
• Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression
• Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta
• Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton
• Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.