CD44 Monoclonal Antibody (OTI1G1), TrueMAB™, OriGene

Description

• CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast
• Several isoforms of CD44 exist, including the predomit CD44H isoform detected in many normal tissues
• CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration
• CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing
• CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential
• CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes
• Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events
• Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined
• Alternative splicing is the basis for the structural and functional diversity of the CD44 protein
• Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus
• CD44 also may be related to tumor metastasis formation.