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50-167-7121

CXCR4 Mouse anti-Human, Clone: 772X122, liquid, TrueMAB™

Manufacturer: OriGene

Select a Size

Pack Size SKU Availability Price
Each of 1 50-167-7121-Each-of-1 In Stock ₹ 46,601.11

50-167-7121 - Each of 1

₹ 46,601.11

In Stock

Quantity

1

Base Price: ₹ 46,601.11

GST (18%): ₹ 8,388.20

Total Price: ₹ 54,989.31

Antigen

CXCR4

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 50% glycerol and 0.05% sodium azide

Gene Accession No.

P61073

Gene Symbols

CXCR4

Immunogen

A near-full length cDNA gene (cytoplasmic C-terminus partially truncated) delivered by DNA immunization

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG2a

Applications

Flow Cytometry, Functional Assay, Inhibition Assays

Clone

772X122

Conjugate

Unconjugated

Gene

CXCR4

Gene Alias

CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

7852

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells
  • CXCR4 has been proved to be the co-receptor for HIV-2′s binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus
  • In other cases, CXCR4 can even function as the only receptor for HIV-2′s binding to the CD4 host cells
  • CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation
  • CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels
  • Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells
  • In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development
  • CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes
  • Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells
  • The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.

Compare Similar Items

Show Difference

Img

OriGene

50-167-7121

--

Antigen:
CXCR4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P61073
Gene Symbols:
CXCR4
Immunogen:
A near-full length cDNA gene (cytoplasmic C-terminus partially truncated) delivered by DNA immunization
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Flow Cytometry, Functional Assay, Inhibition Assays
Clone:
772X122
Conjugate:
Unconjugated
Gene:
CXCR4
Gene Alias:
CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7852
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-167-7123

--

Antigen:
NEUROG1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with <5% trehalose and 0.05% sodium azide
Gene Accession No.:
Q92886
Gene Symbols:
NEUROG1
Immunogen:
Full length human recombit protein of human NEUROG1 produced in HEK293T cell.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA
Clone:
OTI5H10
Conjugate:
Unconjugated
Gene:
NEUROG1
Gene Alias:
AKA, Math4C, NEUROD3, bHLHa6, ngn1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4762
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-167-7124

--

Antigen:
NEUROG1
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with <5% trehalose and 0.05% sodium azide
Gene Accession No.:
Q92886
Gene Symbols:
NEUROG1
Immunogen:
Full length human recombit protein of human NEUROG1 produced in HEK293T cell.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA
Clone:
OTI15A7
Conjugate:
Unconjugated
Gene:
NEUROG1
Gene Alias:
AKA, Math4C, NEUROD3, bHLHa6, ngn1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
4762
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

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OriGene

50-167-7126

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Antigen:
SERPINA1
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with <5% trehalose and 0.05% sodium azide
Gene Accession No.:
P01009
Gene Symbols:
SERPINA1
Immunogen:
Protein expressed in 293T cell transfected with human SERPINA1 expression vector
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA
Clone:
OTI11G2
Conjugate:
Unconjugated
Gene:
SERPINA1
Gene Alias:
A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
5265
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid