KCNIP3 Monoclonal Antibody (OTI3A12), TrueMAB™, OriGene

Description

• Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system
• In the heart, Kv4 channels are involved in the repolarization phase of the action potential
• In the brain however, these channels prevent reverse-propagation of action potentials
• Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins)
• KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function
• There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis
• KChIP3 has activities beyond the modulation of Kv4 currents
• It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos
• Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator
• KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.