PSMA7 Monoclonal Antibody (OTI8B11), TrueMAB™, OriGene

Description

• Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins
• This complex plays numerous essential roles within the cell by associating with different regulatory particles
• Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins
• The 26S proteasome plays a key role in the maintece of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required
• Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation
• This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
• Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions
• The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions
• Plays a role in hepatitis C virus internal ribosome entry site-mediated translation
• Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation.