50-168-4408
ARC Monoclonal Antibody (OTI2H7), TrueMAB™, OriGene
Manufacturer: OriGene
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-168-4408-Each-of-1 | In Stock | ₹ 43,217.21 |
50-168-4408 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,217.21
GST (18%): ₹ 7,779.098
Total Price: ₹ 50,996.308
Antigen
ARC
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
Q7LC44
Gene Symbols
ARC
Immunogen
Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Western Blot
Clone
OTI2H7
Conjugate
Unconjugated
Gene
ARC
Gene Alias
Arg3.1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23237
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Description
- Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system
- ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation
- ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons
- Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory
- Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis
- Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses
- Accumulates at weaker synapses, probably to prevent their undesired enhancement
- This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material
- Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory
- Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1
- In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.
Compare Similar Items
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Antigen: ARC
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q7LC44
Gene Symbols: ARC
Immunogen: Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI2H7
Conjugate: Unconjugated
Gene: ARC
Gene Alias: Arg3.1
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 23237
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
ARC
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q7LC44
Gene Symbols:
ARC
Immunogen:
Human recombit protein fragment corresponding to amino acids 100-396 of human ARC produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI2H7
Conjugate:
Unconjugated
Gene:
ARC
Gene Alias:
Arg3.1
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
23237
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: ATP2A2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: P16615
Gene Symbols: ATP2A2
Immunogen: Human recombit protein fragment corresponding to amino acids 314-756 of human ATP2A2 produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI4B12
Conjugate: Unconjugated
Gene: ATP2A2
Gene Alias: ATP2B, DAR, DD, SERCA2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 488
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
ATP2A2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P16615
Gene Symbols:
ATP2A2
Immunogen:
Human recombit protein fragment corresponding to amino acids 314-756 of human ATP2A2 produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI4B12
Conjugate:
Unconjugated
Gene:
ATP2A2
Gene Alias:
ATP2B, DAR, DD, SERCA2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
488
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: COX17
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: Q14061
Gene Symbols: COX17
Immunogen: Human recombit protein fragment corresponding to amino acids 2-63 of human COX17 produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI1C2
Conjugate: Unconjugated
Gene: COX17
Gene Alias: COX17, cytochrome c oxidase copper chaperone
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10063
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
COX17
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q14061
Gene Symbols:
COX17
Immunogen:
Human recombit protein fragment corresponding to amino acids 2-63 of human COX17 produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI1C2
Conjugate:
Unconjugated
Gene:
COX17
Gene Alias:
COX17, cytochrome c oxidase copper chaperone
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10063
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: HSPA1L
Classification: Monoclonal
Concentration: __
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.: P34931
Gene Symbols: HSPA1L
Immunogen: Human recombit protein fragment corresponding to amino acids 400-641 of human HSPA1L produced in E.coli.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Applications: Western Blot
Clone: OTI3B5
Conjugate: Unconjugated
Gene: HSPA1L
Gene Alias: HSP70-1L, HSP70-HOM, HSP70T, hum70t
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3305
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
HSPA1L
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P34931
Gene Symbols:
HSPA1L
Immunogen:
Human recombit protein fragment corresponding to amino acids 400-641 of human HSPA1L produced in E.coli.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Western Blot
Clone:
OTI3B5
Conjugate:
Unconjugated
Gene:
HSPA1L
Gene Alias:
HSP70-1L, HSP70-HOM, HSP70T, hum70t
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
3305
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid