MLLT10 Rabbit anti-Human, Polyclonal, liquid, OriGene

Description

• Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias
• The 11q23 gene involved in the translocations is MLL
• MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations
• In an analysis of two leukemia patients, the in t(10;11)(p12;q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene
• The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain
• The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10;11)(p12;q14) translocation
• Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10
• The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma
• GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription
• Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.