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50-168-4764

RNF168 Rabbit anti-Human, Mouse, Polyclonal, liquid, OriGene

Manufacturer: OriGene

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Pack Size SKU Availability Price
Each of 1 50-168-4764-Each-of-1 In Stock ₹ 40,931.99

50-168-4764 - Each of 1

₹ 40,931.99

In Stock

Quantity

1

Base Price: ₹ 40,931.99

GST (18%): ₹ 7,367.758

Total Price: ₹ 48,299.748

Antigen

RNF168

Classification

Polyclonal

Formulation

PBS with 50% glycerol and 0.02% sodium azide

Gene Accession No.

Q80XJ2, Q8IYW5

Gene Symbols

RNF168

Immunogen

Recombit protein of human RNF168

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG

Applications

Western Blot

Conjugate

Unconjugated

Gene

RNF168

Gene Alias

hRNF168

Host Species

Rabbit

Purification Method

Antigen Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

165918, 70238

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

Description

  • RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo
  • RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains
  • Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner
  • This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade
  • Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintece
  • At least three isoforms of RNF168 are known to exist.

Compare Similar Items

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Img

OriGene

50-168-4764

--

Antigen:
RNF168
Classification:
Polyclonal
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q80XJ2, Q8IYW5
Gene Symbols:
RNF168
Immunogen:
Recombit protein of human RNF168
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
RNF168
Gene Alias:
hRNF168
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
165918, 70238
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-168-4765

--

Antigen:
BABAM1
Classification:
Polyclonal
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
Q3UI43, Q5XIJ6, Q9NWV8
Gene Symbols:
Babam1
Immunogen:
Recombit protein of human BABAM1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
BABAM1
Gene Alias:
C19orf62, HSPC142, MERIT40, NBA1
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
290631, 29086, 68251
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-168-4767

--

Antigen:
HSPB1
Classification:
Polyclonal
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P04792, P14602
Gene Symbols:
HSPB1
Immunogen:
Recombit protein of human HSPB1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
HSPB1
Gene Alias:
CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15507, 3315
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid

Img

OriGene

50-168-4772

--

Antigen:
UNG
Classification:
Polyclonal
Formulation:
PBS with 50% glycerol and 0.02% sodium azide
Gene Accession No.:
P13051
Gene Symbols:
UNG
Immunogen:
Recombit protein of human UNG
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
UNG
Gene Alias:
DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
7374
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid