AR Mouse anti-Human, Clone: UMAB240, lyophilized, UltraMAB™

Description

• Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No
• 7KMWCO The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
• The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
• The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
• Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
• The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
• The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
• Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy′s disease, and male infertility
• Mutations in this gene are associated with complete androgen insensitivity (CAIS).