50-172-6061

tPA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Manufacturer: Proteintech Group Inc

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Pack Size SKU Availability Price
Each of 1 50-172-6061-Each-of-1 In Stock ₹ 42,443.75

50-172-6061 - Each of 1

₹ 42,443.75

In Stock

Quantity

1

Base Price: ₹ 42,443.75

GST (18%): ₹ 7,639.875

Total Price: ₹ 50,083.625

Antigen

tPA

Classification

Polyclonal

Conjugate

Unconjugated

Gene

PLAT

Gene Alias

Alteplase, plasminogen activator, tissue, PLAT, Reteplase, T PA, t plasminogen activator, Tissue Plasminogen Activator, tPA

Host Species

Rabbit

Purification Method

Antigen Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

18791, 25692, 5327

Content And Storage

-20°C

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration

0.27 mg/mL

Formulation

PBS with 50% glycerol and 0.1% sodium azide; pH 7.3

Gene Accession No.

P00750, P11214, P19637

Gene Symbols

PLAT

Immunogen

tPA Fusion Protein Ag0200

Quantity

150 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
  • By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
  • It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
  • TPA binds to fibrin with high affinity
  • This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
  • Similarly, binding to heparin increases the activation of plasminogen
  • Binding to laminin and fibronectin has also been demonstrated
  • TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
  • These proteins are involved in TPA clearance
  • TPA binds to annexin II and to cytokeratin 8
  • As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
  • In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.

Compare Similar Items

Show Difference

Img

Proteintech Group Inc

50-172-6061

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Antigen:
tPA

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PLAT

Gene Alias:
Alteplase, plasminogen activator, tissue, PLAT, Reteplase, T PA, t plasminogen activator, Tissue Plasminogen Activator, tPA

Host Species:
Rabbit

Purification Method:
Antigen Affinity Chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18791, 25692, 5327

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration:
0.27 mg/mL

Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3

Gene Accession No.:
P00750, P11214, P19637

Gene Symbols:
PLAT

Immunogen:
tPA Fusion Protein Ag0200

Quantity:
150 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

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50-172-6062

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Antigen:
NSE

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ENO2

Gene Alias:
enolase 2 (gamma, neuronal), Gamma enolase, Neural enolase, Neuron specific enolase, NSE

Host Species:
Rabbit

Purification Method:
Antigen Affinity Chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
13807, 2026, 24334

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration:
0.23 mg/mL

Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3

Gene Accession No.:
P07323, P09104, P17183

Gene Symbols:
ENO2

Immunogen:
NSE Fusion Protein Ag0196

Quantity:
150 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Proteintech Group Inc

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Antigen:
GNAS

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
GNAS

Gene Alias:
AHO, C20orf45, GNAS, GNAS complex locus, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, POH

Host Species:
Rabbit

Purification Method:
Antigen Affinity Chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
14683, 2778

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration:
0.17 mg/mL

Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3

Gene Accession No.:
P84996, Q6R0H6

Gene Symbols:
Gnas

Immunogen:
GNAS Fusion Protein Ag0197

Quantity:
150 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Img

Proteintech Group Inc

50-172-6066

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Antigen:
Annexin VII

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
ANXA7

Gene Alias:
Annexin 7, annexin A7, Annexin VII, Annexin7, ANX7, ANXA7, SNX, SYNEXIN

Host Species:
Rabbit

Purification Method:
Antigen Affinity Chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11750, 310

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Concentration:
0.13 mg/mL

Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3

Gene Accession No.:
P20073, Q07076

Gene Symbols:
ANXA7

Immunogen:
Annexin VII Fusion Protein Ag0206

Quantity:
150 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG