PCBP2 Rabbit anti-Human, Polyclonal, Proteintech

Description

• This antibody is a rabbit polyclonal antibody raised against a full-length human PCBP2 protein
• The protein encoded by this gene appears to be multifunctional
• Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins
• The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding
• Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure
• It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA
• The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability
• This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2
• This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes
• Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2)
• Multiple transcript variants encoding different isoforms have been found for this gene.