Presenilin-1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Description

• This antibody is specific to isoform 1 (53 kDa), isoform 2 (52 kDa), isoform 4 (21 kDa), isoform 7 (49 kDa) of this protein
• Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer′s disease
• In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer
• This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer′s disease
• Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site)
• It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer′s disease
• Multiple isoforms of presenilin1 are known to exist
• This antibody has no cross-reactivity to presenilin2.