Adenosine A1 Receptor Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Description

• Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily
• Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3)
• Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission
• The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro
• In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores
• Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system
• A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release
• In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake
• Other tissues also express A1AR including kidney and testis.