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50-173-3606

ROCK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Manufacturer: Proteintech Group Inc

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Pack Size SKU Availability Price
Each of 1 50-173-3606-Each-of-1 In Stock ₹ 44,150.23

50-173-3606 - Each of 1

₹ 44,150.23

In Stock

Quantity

1

Base Price: ₹ 44,150.23

GST (18%): ₹ 7,947.041

Total Price: ₹ 52,097.271

Antigen

ROCK1

Classification

Polyclonal

Conjugate

Unconjugated

Gene

ROCK1

Gene Alias

p160 ROCK 1, P160ROCK, PRO0435, ROCK1

Host Species

Rabbit

Purification Method

Antigen Affinity Chromatography

Regulatory Status

RUO

Gene ID (Entrez)

19877, 6093, 81762

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot

Concentration

0.35 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.3

Gene Accession No.

P70335, Q13464, Q63644

Gene Symbols

ROCK1

Immunogen

ROCK1 Fusion Protein Ag16317

Quantity

150 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Description

  • The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate
  • ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition
  • The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation
  • ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region
  • They are joined by a variable region that contains the Rho-binding domain
  • During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity
  • The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.

Compare Similar Items

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Img

Proteintech Group Inc

50-173-3606

--

Antigen:
ROCK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ROCK1
Gene Alias:
p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19877, 6093, 81762
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.35 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P70335, Q13464, Q63644
Gene Symbols:
ROCK1
Immunogen:
ROCK1 Fusion Protein Ag16317
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG

Img

Proteintech Group Inc

50-173-3609

--

Antigen:
NR3C2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NR3C2
Gene Alias:
MCR, Mineralocorticoid receptor, MLR, MR, NR3C2
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
110784, 25672, 4306
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
0.53 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P08235, P22199, Q8VII8
Gene Symbols:
NR3C2
Immunogen:
NR3C2 Fusion Protein Ag16410
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG

Img

Proteintech Group Inc

50-173-3613

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Antigen:
PCDH10
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PCDH10
Gene Alias:
KIAA1400, OL PCDH, PCDH10, protocadherin 10
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18526, 57575
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.2 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9P2E7
Gene Symbols:
Pcdh10
Immunogen:
PCDH10 Fusion Protein Ag16494
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG

Img

Proteintech Group Inc

50-173-3614

--

Antigen:
DOCK4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DOCK4
Gene Alias:
dedicator of cytokinesis 4, DOCK4, KIAA0716
Host Species:
Rabbit
Purification Method:
Antigen Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9732
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
0.34 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q8N1I0
Gene Symbols:
DOCK4
Immunogen:
DOCK4 Fusion Protein Ag16516
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG