PIGR Rabbit anti-Human, Polyclonal, Proteintech

Description

• Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells
• Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium
• pIgR associates with secreted dimeric IgA and IgM molecules
• During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor
• When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process
• SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids
• The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein
• The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.