PXMP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Description

• Peroxisomes are subcellular organelles with important functions in lipid metabolism that are found in virtually all eucaryotic cells
• The peroxisomal membrane contains a number of integral and peripheral membrane proteins involved in the import of peroxisomal matrix proteins and the transport of metabolites across the membrane
• Pxmp2 (Peroxisomal membrane protein 2), also known as PMP22, is a 195 amino acid multi-pass membrane protein that belongs to the peroxisomal membrane protein PXMP2/4 family
• The Pxmp2 protein interacts with both Peroxin 19 and Siva proteins
• The Peroxin 19 protein binds multiple peroxisomal membrane proteins (PMPs), is predomitly cytoplasmic, and is required for peroxisome membrane synthesis
• Pxmp2 is the most abundant peroxisomal membrane protein in higher eukaryotes
• Pxmp2′s expression is tissue-specific with highest levels of expression in liver, kidney and heart tissue
• It has been suggested that Pxmp2 is involved in pore-forming activity and may contribute to the broad permeability of the peroxisomal membrane
• Disruption of the mouse Pxmp2 gene leads to partial restriction of peroxisomal membrane permeability to solutes in vitro and in vivo
• The Pxmp2 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly and mosquito, and maps to human chromosome 12q24.33.