beta Amyloid (C-Terminal) Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Description

• Amyloid beta peptide (Abeta) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer′s disease
• This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process
• The first step involves cleavage of the extracellular, amino-terminal domain of beta APP
• Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE)
• This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin
• Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remt
• This remt is then processed by another protease termed gamma-secretase
• Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide
• Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components
• Found associated with the presenilins is the transmembrane glycoprotein nicastrin
• Nicastrin has been found to bind to the carboxyl-terminus of betaAPP and helps to modulate the production of the amyloid beta peptide Also found in the neurofibrillary lesions in Alzheimer′s disease is the protein termed Tau
• Tau is a neuronal microtubule-associated protein found predomitly on axons
• The function of tau is to promote tubulin polymerization and stabilize microtubules
• Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), which is the building block of neurofibrillary lesions in Alzheimer′s disease brain.