ATP1A3 (middle) Rabbit anti-Human, Polyclonal, Proteintech

Description

• This antibody is generated against the middle region (378-580aa) of ATP1A3 and detects 113 kDa protein in SDS-PAGE
• The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane
• This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA)
• The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit
• Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families
• The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression
• The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression
• The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.