PTBP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Description

• This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs)
• The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA)
• These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport
• While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm
• The hnRNP proteins have distinct nucleic acid binding properties
• The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs
• This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway
• It may also promote the binding of U2 snRNP to pre-mRNAs
• This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure
• Alternatively spliced transcript variants encoding different isoforms have been described.