IGFBP5 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Description

• This antibody is specific to IGFBL5
• The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs
• They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system
• Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment
• In addition, the IGFBPs appear to have biological activity independent of the IGFs
• Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors
• For instance, IGFBP1 is negatively regulated by insulin production
• The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes
• It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues
• It is expressed in several human tissues including fetal eye and fetal brain
• IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs
• Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury
• IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.