50-173-6821
VPRBP Mouse anti-Human, Clone: 1A7A8, Proteintech
Manufacturer: Proteintech Group Inc
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-6821-Each-of-1 | In Stock | ₹ 42,443.75 |
50-173-6821 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,443.75
GST (18%): ₹ 7,639.875
Total Price: ₹ 50,083.625
Antigen
VPRBP
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q9Y4B6
Gene Symbols
DCAF1
Immunogen
VPRBP Fusion Protein Ag2184
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
1A7A8
Conjugate
Unconjugated
Gene
DCAF1
Gene Alias
DCAF1, HIV 1 Vpr binding protein, KIAA0800, Protein VPRBP, RIP, Vpr (HIV 1) binding protein, Vpr interacting protein, VPRBP
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
9730
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification
- Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2
- Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex
- The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination
- Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition
- Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of ′Thr-120′ of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription
- H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors
- Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2
- In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase
- The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT
- In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
Compare Similar Items
Show Difference
Antigen: VPRBP
Classification: Monoclonal
Concentration: 2 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q9Y4B6
Gene Symbols: DCAF1
Immunogen: VPRBP Fusion Protein Ag2184
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1A7A8
Conjugate: Unconjugated
Gene: DCAF1
Gene Alias: DCAF1, HIV 1 Vpr binding protein, KIAA0800, Protein VPRBP, RIP, Vpr (HIV 1) binding protein, Vpr interacting protein, VPRBP
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 9730
Content And Storage: -20°C
Form: Liquid
Antigen:
VPRBP
Classification:
Monoclonal
Concentration:
2 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9Y4B6
Gene Symbols:
DCAF1
Immunogen:
VPRBP Fusion Protein Ag2184
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1A7A8
Conjugate:
Unconjugated
Gene:
DCAF1
Gene Alias:
DCAF1, HIV 1 Vpr binding protein, KIAA0800, Protein VPRBP, RIP, Vpr (HIV 1) binding protein, Vpr interacting protein, VPRBP
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
9730
Content And Storage:
-20°C
Form:
Liquid
Antigen: CD36
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P16671
Gene Symbols: CD36
Immunogen: CD36 Fusion Protein Ag13541
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1A8C5
Conjugate: Unconjugated
Gene: CD36
Gene Alias: CD36, CHDS7, FAT, Fatty acid translocase, Glycoprotein IIIb, GP3B, GP4, GPIIIB, GPIV, PAS 4, PAS IV, PASIV, Platelet collagen receptor, Platelet glycoprotein 4, Platelet glycoprotein IV, SCARB3, Thrombospondin receptor
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 948
Content And Storage: -20°C
Form: Liquid
Antigen:
CD36
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P16671
Gene Symbols:
CD36
Immunogen:
CD36 Fusion Protein Ag13541
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1A8C5
Conjugate:
Unconjugated
Gene:
CD36
Gene Alias:
CD36, CHDS7, FAT, Fatty acid translocase, Glycoprotein IIIb, GP3B, GP4, GPIIIB, GPIV, PAS 4, PAS IV, PASIV, Platelet collagen receptor, Platelet glycoprotein 4, Platelet glycoprotein IV, SCARB3, Thrombospondin receptor
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
948
Content And Storage:
-20°C
Form:
Liquid
Antigen: NF-M
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P07197, P08553, P12839
Gene Symbols: Nefm
Immunogen: NF-M Fusion Protein Ag22709
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 2E3B12
Conjugate: Unconjugated
Gene: NEFM
Gene Alias: 160 kDa neurofilament protein, NEF3, NEFM, Neurofilament 3, NF M, NFM
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 18040, 24588, 4741
Content And Storage: -20°C
Form: Liquid
Antigen:
NF-M
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P07197, P08553, P12839
Gene Symbols:
Nefm
Immunogen:
NF-M Fusion Protein Ag22709
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
2E3B12
Conjugate:
Unconjugated
Gene:
NEFM
Gene Alias:
160 kDa neurofilament protein, NEF3, NEFM, Neurofilament 3, NF M, NFM
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
18040, 24588, 4741
Content And Storage:
-20°C
Form:
Liquid
Antigen: Plasminogen
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P00747
Gene Symbols: PLG
Immunogen: Plasminogen Fusion Protein Ag9938
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1F6A11
Conjugate: Unconjugated
Gene: PLG
Gene Alias: Angiostatin, plasminogen, PLG
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 5340
Content And Storage: -20°C
Form: Liquid
Antigen:
Plasminogen
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P00747
Gene Symbols:
PLG
Immunogen:
Plasminogen Fusion Protein Ag9938
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1F6A11
Conjugate:
Unconjugated
Gene:
PLG
Gene Alias:
Angiostatin, plasminogen, PLG
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
5340
Content And Storage:
-20°C
Form:
Liquid