50-173-7184
ROCK1 Mouse anti-Human, Mouse, Rat, Clone: 3G5E12, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-7184-Each-of-1 | In Stock | ₹ 42,443.75 |
50-173-7184 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,443.75
GST (18%): ₹ 7,639.875
Total Price: ₹ 50,083.625
Antigen
ROCK1
Classification
Monoclonal
Concentration
0.8 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
P70335, Q13464, Q63644
Gene Symbols
ROCK1
Immunogen
ROCK1 Fusion Protein Ag16317
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Western Blot
Clone
3G5E12
Conjugate
Unconjugated
Gene
ROCK1
Gene Alias
p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
19877, 6093, 81762
Content And Storage
-20°C
Form
Liquid
Description
- The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate
- ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition
- The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation
- ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region
- They are joined by a variable region that contains the Rho-binding domain
- During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity
- The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.
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Antigen: ROCK1
Classification: Monoclonal
Concentration: 0.8 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P70335, Q13464, Q63644
Gene Symbols: ROCK1
Immunogen: ROCK1 Fusion Protein Ag16317
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: 3G5E12
Conjugate: Unconjugated
Gene: ROCK1
Gene Alias: p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 19877, 6093, 81762
Content And Storage: -20°C
Form: Liquid
Antigen:
ROCK1
Classification:
Monoclonal
Concentration:
0.8 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P70335, Q13464, Q63644
Gene Symbols:
ROCK1
Immunogen:
ROCK1 Fusion Protein Ag16317
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
3G5E12
Conjugate:
Unconjugated
Gene:
ROCK1
Gene Alias:
p160 ROCK 1, P160ROCK, PRO0435, ROCK1
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
19877, 6093, 81762
Content And Storage:
-20°C
Form:
Liquid
Antigen: SOX10
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P56693
Gene Symbols: SOX10
Immunogen: SOX10 Fusion Protein Ag23191
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1D2C8
Conjugate: Unconjugated
Gene: SOX10
Gene Alias: DOM, SOX10, Transcription factor SOX 10, WS2E, WS4
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 6663
Content And Storage: -20°C
Form: Liquid
Antigen:
SOX10
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P56693
Gene Symbols:
SOX10
Immunogen:
SOX10 Fusion Protein Ag23191
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1D2C8
Conjugate:
Unconjugated
Gene:
SOX10
Gene Alias:
DOM, SOX10, Transcription factor SOX 10, WS2E, WS4
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
6663
Content And Storage:
-20°C
Form:
Liquid
Antigen: CFP
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P27918
Gene Symbols: CFP
Immunogen: CFP Fusion Protein Ag9798
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: 1D5A9
Conjugate: Unconjugated
Gene: CFP
Gene Alias: BFD, CFP, Complement factor P, complement factor properdin, PFC, PFD, PROPERDIN
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 5199
Content And Storage: -20°C
Form: Liquid
Antigen:
CFP
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P27918
Gene Symbols:
CFP
Immunogen:
CFP Fusion Protein Ag9798
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
1D5A9
Conjugate:
Unconjugated
Gene:
CFP
Gene Alias:
BFD, CFP, Complement factor P, complement factor properdin, PFC, PFD, PROPERDIN
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
5199
Content And Storage:
-20°C
Form:
Liquid
Antigen: p57Kip2
Classification: Monoclonal
Concentration: 0.7 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.: P49918, P49919
Gene Symbols: CDKN1C
Immunogen: p57Kip2 Fusion Protein Ag19927
Quantity: 150 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: 1A12H3
Conjugate: Unconjugated
Gene: CDKN1C
Gene Alias: BWCR, BWS, CDKN1C, KIP2, p57, p57 Kip2, p57Kip2, WBS
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 1028, 12577, 246060
Content And Storage: -20°C
Form: Liquid
Antigen:
p57Kip2
Classification:
Monoclonal
Concentration:
0.7 mg/mL
Formulation:
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.:
P49918, P49919
Gene Symbols:
CDKN1C
Immunogen:
p57Kip2 Fusion Protein Ag19927
Quantity:
150 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
1A12H3
Conjugate:
Unconjugated
Gene:
CDKN1C
Gene Alias:
BWCR, BWS, CDKN1C, KIP2, p57, p57 Kip2, p57Kip2, WBS
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
1028, 12577, 246060
Content And Storage:
-20°C
Form:
Liquid