CD126 Monoclonal Antibody (B-R6), eBioscience™, Invitrogen™

Description

• Description: Recognizes soluble and membranous human IL-6R
• This Antibody has been shown to inhibit IL-6 mediated proliferation of XG-1 cells, and partially blocks binding of IL-6 to its receptor
• BMS135 is applicable for FACS analysis IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response
• It has been recognized to be a member of the alpha-helical cytokine family
• IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues
• Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding
• The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6
• A soluble form of the human gp80 protein has been detected in serum and urine samples
• This 55 kDa protein representing the extracellular portion of gp80 is generated by shedding, a process that seems to be controlled by protein kinase C
• It is still functional, indicating that soluble gp80 plays a biological role in promoting IL-6 activity
• Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor
• This gene encodes a subunit of the interleukin 6 (IL6) receptor complex
• Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response
• The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines
• Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer
• Alternatively spliced transcript variants encoding distinct isoforms have been reported
• A pseudogene of this gene is found on chromosome 9.