CD154 (CD40 Ligand) Monoclonal Antibody (MK13A4), eBioscience™, Invitrogen™

Description

• Description: CD40 belongs to the TNF receptor superfamily and is a biochemical marker for the identification of activated platelets of patients with cardiovascular diseases (angina pectoris, infarction, stroke etc.) A key role of CD40/CD40ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated
• CD40 Ligand is expressed on the surface of activated CD4+ T cells, basophils, and mast cells
• Binding of CD40L to its receptor, CD40, on the surface of B cells stimulates B-cell proliferation, adhesion and differentiation
• A soluble isoform of CD40L has been shown to exist in the circulation
• This soluble molecule is a homotrimer of a 18kDa protein exhibiting full activity in B cell proliferation and differentiation assays, is able to rescue B cells from apoptosis and binds soluble CD40
• CD40L is discussed in relation to a potential role in supporting B cell tumors and it has been discovered that the molecular defect in the X-linked Hyper-IgM-Syndrome is targeted to the CD40 L gene, it is functional involved in B cell hybridomas and chronic lymphocytic leukemia as well as several autoimmune diseases
• BMS153 was found to block binding of CD40Ligand to its receptor CD40
• Applications Tested: Functional Studies (Blocking)
• CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells
• The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines
• CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes
• It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.